VBL Presents New Data on MOSPD2 Antibodies as Potential Treatment for NASH and Colitis at DDW
- Study was rated in the top 10% of all abstracts in this category and was selected as Poster of Distinction
- Data demonstrate the potential of VBL's proprietary MOSPD2 mAbs for chronic inflammatory indications, via a novel and distinct mechanism targeting monocyte migration
Studies have emphasized the crucial role of infiltrating monocytes/macrophages for the progression of liver inflammation and fibrosis in experimental mouse models and in patients with liver cirrhosis. Peripheral monocytes are also involved in inflammatory bowel disease (IBD) pathogenesis, as circulating monocytes were shown to accumulate in the inflamed gut of IBD patients and promote the production of pro-inflammatory cytokines. VBL's data demonstrate that MOSPD2 plays a role in the pathogenesis of NASH and colitis, by inhibiting the accumulation of monocytes in the affected tissue. Targeting of MOSPD2 using specific monoclonal antibodies, such as the proprietary ones developed by VBL, may offer a novel and distinct treatment for chronic immune-inflammatory indications including colitis and NASH. In the NASH landscape, VBL's differentiated approach opens a possibility for treatment of patients with established disease, whose liver has advanced to stages of inflammation and fibrosis.
"These new data, which add to our promising results in multiple sclerosis and rheumatoid arthritis models, are encouraging as we continue to advance our candidate VB-601 towards first-in-man," said Dror Harats, M.D., Chief Executive Officer of
About VBL's VB-600 Platform
VBL is conducting two parallel drug development programs that are exploring the potential of MOSPD2 (motile sperm domain-containing protein 2), a protein that VBL has identified as a key regulator of cell motility, as a therapeutic target for inflammatory diseases and cancer. Our VB-600 platform comprises classical anti-MOSPD2 monoclonal antibodies for inflammatory indications, as well as bi-specific antibody candidates for oncology.
Forward Looking Statements
This press release contains forward-looking statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as “anticipate,” “believe,” “could,” “estimate,” “expect,” “goal,” “intend,” “look forward to,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” and similar expressions. These forward-looking statements may include, but are not limited to, statements regarding our programs, including MOSPD2, including their clinical development, therapeutic potential and clinical results. These forward-looking statements are not promises or guarantees and involve substantial risks and uncertainties. Among the factors that could cause actual results to differ materially from those described or projected herein include uncertainties associated generally with research and development, clinical trials and related regulatory reviews and approvals, the risk that historical clinical trial results may not be predictive of future trial results, that our financial resources do not last for as long as anticipated, and that we may not realize the expected benefits of our intellectual property protection. A further list and description of these risks, uncertainties and other risks can be found in our regulatory filings with the U.S. Securities and Exchange Commission, including in our annual report on Form 20-F for the year ended December 31, 2019, and subsequent filings with the SEC. Existing and prospective investors are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. VBL Therapeutics undertakes no obligation to update or revise the information contained in this press release, whether as a result of new information, future events or circumstances or otherwise.
Source: VBL Therapeutics