VBL Presents New Data on the Potential of its Novel anti-MOSPD2 Monoclonal Antibodies for Rheumatoid Arthritis at the EULAR 2020 Congress
VBL's new data highlight several key findings:
- Clinical relevance for RA: Biopsies from RA patients demonstrate strong staining for monocytes expressing MOSPD2. Monocytes are immune cells that play a pivotal role in the progression of various inflammatory diseases. VBL's antibodies can inhibit monocyte migration by up to 90% in a mouse model.
- MOSPD2 plays a key role in RA: Mice in which the MOSPD2 gene was knocked out essentially do not develop disease in the Collagen Antibody-Induced Arthritis model for RA.
- Therapeutic potential: Treatment with anti-MOSPD2 mAb significantly inhibited arthritis progression in the Collagen-Induced Arthritis model (p<0.005). The treatment reduced >50% of disease severity and blocked further disease progression.
- Differentiation: Anti-MOSPD2 demonstrated higher activity than anti-TNFa in the advanced phase of the disease.
"These encouraging results may open new possibilities for treatment of anti-MOSPD2 antibodies for RA," said
The new results add to a growing body of data demonstrated activity of VBL's antibodies in models of multiple sclerosis, nonalcoholic steatohepatitis and colitis. VBL continues to advance lead candidate VB-601 towards a first-in-man study, which is expected to begin in 2021.
For a link to VBL's presentation at the
About VBL's VB-600 Platform
VBL is conducting two parallel drug development programs that are exploring the potential of MOSPD2 (motile sperm domain-containing protein 2), a protein that VBL has identified as a key regulator of cell motility, as a therapeutic target for inflammatory diseases and cancer. Our VB-600 platform comprises classical anti-MOSPD2 monoclonal antibodies for inflammatory indications, as well as bi-specific antibody candidates for oncology.
Forward Looking Statements
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Source: VBL Therapeutics